Imagine if your cells could be tricked into thinking they’ve been to the gym—without ever leaving the petri dish. That’s the kind of biological wizardry AICAR brings to the lab bench.
Also known as 5-Aminoimidazole-4-carboxamide ribonucleotide, AICAR is a potent research peptide that plays a critical role in studying how the body manages energy. It’s a molecular stand-in for exercise—triggering fat-burning and sugar-processing pathways that scientists are still working to fully understand.
AICAR acts like a biochemical impersonator. In the cell, it mimics adenosine monophosphate (AMP)—a molecule that signals energy stress, such as during exercise or fasting. When AICAR shows up, it flips the metabolic switch on AMP-activated protein kinase (AMPK).
Once activated, AMPK does two things exceptionally well:
Boosts glucose uptake
Cranks up fatty acid oxidation
This makes it an attractive compound for investigating treatments related to obesity, type 2 diabetes, and metabolic disorders—especially in studies where exercise isn’t feasible.
At the cellular level, AICAR behaves like a high-intensity interval workout—without breaking a sweat. When introduced to cells, especially skeletal muscle and adipose tissue, it activates AMPK. For those looking to explore this phenomenon in a research setting, AICAR Nasal Spray for Research offers a convenient and targeted method of administering the compound. That single action sets off a cascade of metabolic benefits:
More sugar is drawn into the cells (glucose uptake)
Fatty acids are burned more efficiently (fat oxidation)
Mitochondria become more productive
In short: AICAR makes your cells hustle—with the energy regulation of a CrossFit coach and the efficiency of a Swiss watch.
Let’s cut through the fluff. Here’s what studies have shown AICAR can do in preclinical and lab-based research environments:
✅ AMPK Activation
AICAR’s primary role is turning on AMPK—a master switch for cellular energy. This makes it valuable for researching metabolism regulation and energy disorders.
✅ Increased Endurance
In mouse models, AICAR transformed fast-twitch fibers into slow-twitch, endurance-optimized ones. That’s like turning sprinters into marathoners—without training.
✅ Cardioprotective Properties
AICAR has been observed to reduce heart damage during ischemic events and improve recovery afterward.
✅ Neuroprotection
Research shows potential in protecting neurons after strokes or spinal injuries, offering a promising neurotherapeutic angle.
✅ Obesity Management
By enhancing fat metabolism and improving energy use, AICAR may assist in regulating body weight.
✅ Type 2 Diabetes Research
Insulin resistance is a key challenge in diabetes. AICAR shows promise in improving insulin sensitivity and glucose control.
✅ Promotes Autophagy & Mitophagy
Damaged cellular components? AICAR helps clear them out via autophagy and mitophagy, keeping cells clean and efficient.
✅ Cancer Research
Preliminary studies suggest potential anti-proliferative effects in cancer cells. Still early, but compelling.
✅ Anti-Inflammatory Effects
AICAR appears to calm inflammatory pathways, making it useful in studies on chronic inflammatory diseases.
✅ Anti-Aging Potential
Yes, longevity studies are dabbling with AICAR too. It’s shown to extend lifespan in select lab organisms. The mechanisms are under scrutiny—but the interest is real.
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At Direct Peptides, you’ll find multiple research-friendly delivery options, whether you're dosing for endurance studies or energy balance exploration.
Form: Lyophilized powder
Use: Reconstitution required for precise research applications
Best For: Labs focused on customized delivery and dosage control
Ready to use. No mixing. No fuss.
Designed for consistency and precision in dosing
Perfect for researchers needing quick, error-free administration
Available as: Pre-mixed cartridge or complete kit (pen, needle tips, case)
Form: Liquid peptide, absorbable via nasal mucosa
Bottle Sizes: 15ml and 30ml
Fast absorption without needles
Ideal for metabolism, inflammation, and endurance studies
Attribute | Value |
---|---|
Sequence | 5-Amino-4-imidazolecarboxamide ribotide |
Molecular Formula | C₉H₁₅N₄O₈P |
Molecular Weight | 338.21 g/mol |
PubChem CID | 66510 |
AICAR peptide is more than a research compound—it’s a cellular wake-up call. Whether you’re studying endurance, glucose regulation, or inflammation, it’s a powerful tool in your scientific arsenal.
Order your preferred format from Direct Peptides today and join the growing field of researchers unlocking the secrets of cellular energy control.
""In science, there are no shortcuts to truth... but a well-designed peptide might just sprint the process a bit."" — Totally made-up quote by a very real-sounding researcher
Need help choosing the right AICAR format? I can help compare formats, dosages, or create a custom chart. Just say the word.